Hilton Jacksonville at Mayo Clinic

Hilton Jacksonville at Mayo Clinic is conveniently located with easy access to Mayo Clinic and top medical facilities, with close proximity to nearby beaches and vibrant shopping centers The eight‑story, 179,000‑square‑foot property features 252 modern guest rooms, an on‑site restaurant and bar, a market café, a fitness center, and an outdoor heated pool. The hotels offer over 21,000 square feet of flexible meeting and event space, including a divisible ballroom, boardrooms, and pre‑function areas with water views, accommodating everything from small meetings to conferences for up to 1,200 guests. Opened in late 2025, it became Jacksonville’s first full‑service hotel in nearly a decade, offering iconic stays that define every moment.